Little Red Ribbon-Hood: September 2006: Archives

September 7, 2006

A Guide To The ABC's For Dummies genre: Gaylingual & Little Red Ribbon-Hood & Six Degrees of Speculation & Snapshot Thoughts & Tongue-In-Cheek

ABC's For Dummies

Daniel DiRito | September 7, 2006 | 3:07 PM | link | Comments (5)
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September 4, 2006

Feeding Frenzy: What's Eating Us? genre: Indie-Script & Little Red Ribbon-Hood & Nouveau Thoughts

Feeding frenzy

We live in a world that likes to focus on flash...the best news is breaking news that portrays the latest tragedy...whether that be a plane crash, a shooting, or any of a number of calamities. At the same time, slower burning, less inflammatory catastrophes unfold at a reliably steady pace each day. The question is what makes one the focus of near obsessive attention and the other an item to be placed obscurely on the back burner?

A new article points to a classic example of this phenomenon...the expansion of humanity...around the waist. While we do see an occasional news piece on the topic, it rarely breaches the psyche to the same degree that, for example, the number of U.S. troop fatalities in Iraq has achieved. Clearly, many Americans could cite the number of troops lost but only perhaps a handful could offer the statistics on deaths attributed to obesity. The full article can be read here.

SYDNEY, Australia (AP) - An obesity pandemic threatens to overwhelm health systems around the globe with illnesses such as diabetes and heart disease, experts at an international conference warned Sunday.

"This insidious, creeping pandemic of obesity is now engulfing the entire world," Paul Zimmet, chairman of the meeting of more than 2,500 experts and health officials, said in a speech opening the weeklong International Congress on Obesity. "It's as big a threat as global warming and bird flu."

The World Health Organization says more than 1 billion adults are overweight and 300 million of them are obese, putting them at much higher risk of diabetes, heart problems, high blood pressure, stroke and some forms of cancer.

Zimmet, a diabetes expert at Australia's Monash University, said there are now more overweight people in the world than the undernourished, who number about 600 million.

I found the information in the last paragraph fascinating...overweight people now outnumber the undernourished! The reason I find it fascinating may surprise my readers...but I guess the element of surprise may well be what we all prefer. It is fascinating to me because it seems to be consistent with the polarization that permeates the United States and much of the world...perhaps a further sign that humanity is woefully out of largely at the extremes.

As I began to ponder these thoughts, I recalled the recent media focus on the arrest of a suspect in the JonBenet Ramsey murder. Many within the blogosphere marveled at the incessant coverage of that event and a number wrote about the apparent misplaced focus given the numerous problems facing the U.S. and the world. I may have missed it, but I don't recall a lot of analysis addressing why this was happening and why it frequently happens. In my own mental musings, it struck me that both the obesity issue and the JonBenet Ramsey case were about consumption...the feeding frenzy.

So what is it that we're feeding? The question brings to mind something my dad likes to discuss...that being what makes sports teams and sporting events so popular. His theory has always made sense to me and it seems to fit into the topic of this posting. As my dad explains it, little in life offers clarity...we frequently navigate this life with the uncertainty and the anxiety one might equate with the structure of a movie. Each of us is attempting to complete the movie that is our own life story but it can't be done in two hours or with the formulaic structure that makes the movie watching experience so satisfying. Further, the ending is virtually unknown.

The same is true of a sporting event...there is a clear objective, a defined set of rules, a finite time frame, and a winner and a loser...all achieved in a few hours...but notably absent the same tangible consequences our own life choices may bring. In essence, these events are an opportunity to be a voyeur rather than a player. It is a detached opportunity to step away from the realities of ones own existence and engage in a moment of fantasy acted out by others and providing a fifty-fifty opportunity to be a winner...a statistical equation that we must find at least equal to, or, perhaps more favorable than the odds we apply to our own potential for a "successful" outcome.

Food neatly fits into this equation in that it sustains ones opportunity to remain in the provides the promise of more time to succeed...or its absence foretells of our likely demise. As the world (our daily existence) has become more convoluted and uncertain, we are apt to migrate towards those things that offer a degree of certainty. Food and sports events provide those outlets...and situations like the JonBenet Ramsey arrest or the tsunami or Katrina give us reference points that reinforce our ability to conclude that our own life isn't so bad in comparison to many others.

Unfortunately, what this becomes is the process of living life by substitution. Each pound gained is symbolically the weight of our own unresolved anxiety and each time we subjugate our own success to a victory won by our favorite sports team, we begin to lose sight of our own struggle...feeding more and more on the junk food of life in an effort to ignore our own obstacles and the need to execute our own game plan. The feeding cycle expands and so do we in a perpetual process of denial...reinforced by our own observations of those who surround we each expand our own denial we find reassurance in those who surround us.

Sadly, that denial also leads us to effectively ignore those who suffer the deprivations we fear...their plight must be ignored because they serve to amplify the anxiety inherent in our uniquely human awareness of our mortality. Counter intuitively, we use tragedy and suffering...self-administered in front of the television in measured the tonic of comparison. Not only do we watch the suffering in New Orleans to support our favorable existence...we must have it in order to sustain ourselves.

We send an occasional donation or invoke our outrage at the government or any number of responsible "others" in order to offset the guilt that is bound to percolate to the surface from time to time...but we do so again to feed ourselves. We choose political and ideological sides because these false constructs provide the means and the mechanism to abandon our humanity. We change the debate and the dialogue into an abstraction similar to a sporting event which provides each of us with the institutional cover necessary to detach from the ethical bankruptcy that threatens our consciousness and we feed its falsity with the frenzy of fanaticism.

Yes, there is an "insidious, creeping pandemic". And yes, it is fueled by consumption...but in a quintessential irony, it is our humanity that we are consuming. Unless we begin to value and seek more "truth", we will devour ourselves into oblivion.

Cross posted at Donklephant

Daniel DiRito | September 4, 2006 | 11:18 AM | link | Comments (1)
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September 1, 2006

HIV Vaccines Show Early Promise genre: Gaylingual & Little Red Ribbon-Hood

Fighting HIV

The search for a vaccine for HIV has been underway for over two decades with little success although scientists have continued to better understand how the virus is able to defeat the body’s immune system. Presently, there are numerous vaccines in development that seek to defeat the virus with a variety of novel approaches. News about recent vaccine trials just released offer promising data suggesting they have achieved notable immune responses. The first vaccine data was reported at a four day vaccine conference in Amsterdam. Read the full article here.

A Swedish HIV vaccine study conducted by researchers at Karolinska Institutet (KI), Karolinska University Hospital and the Swedish Institute for Infectious Disease Control (SMI) has produced surprisingly good results.

Over 90 per cent of the subjects in the phase 1 trials developed an immune response to HIV. "Never has such a good result been seen with a vaccine of this type," says Professor Eric Sandström, Chief Physician at Karolinska University Hospital.

The vaccine is what is known as a genetic vaccine, which uses parts of the virus DNA to stimulate the rapid endogenous production of the proteins for which the injected DNA codes.

The trial subjects were vaccinated on three occasions with this vaccine using a needle-free method of injection. In order to enhance the effect, the researchers also gave the subjects a fourth dose of a vaccine in which parts of the HIV virus DNA had been integrated into another virus (vaccinia = the cowpox virus). This vaccine-based HIV vaccine is produced by the USA’s National Institutes of Health and was donated for use in this Swedish study.

“Our vaccine is designed in such a way that it’s able to protect against many of the circulating HIV types in Africa and the West," says Professor Britta Wahren at the SMI/KI.

The vaccine was delivered with a new needle free process that uses an air blast to inject the vaccine into the skin of the recipient. The process is designed to expose the vaccine over a wider area in order to involve more of the body’s immune mechanisms. The results seem to suggest that the delivery system may have been beneficial.

A second article reports on the early results of another vaccine candidate. Read the full article here.

SAN DIEGO, Aug. 31 /PRNewswire-FirstCall/ -- Vical Incorporated (Nasdaq: VICL - News) announced today that a "prime-boost" vaccine regimen tested in 40 HIV-uninfected subjects in a National Institutes of Health (NIH) sponsored Phase 1 clinical trial was safe and well-tolerated, and was highly effective in inducing T-cell immune responses with multiple functions that may be important for controlling HIV infection. The trial involved priming an immune response with three doses of a plasmid DNA vaccine, based on Vical's proprietary DNA delivery technology, and boosting the response with a single dose of adenoviral vector vaccine given at a later date.

The vaccine incorporates HIV genetic material from the three most globally important HIV subtypes, clades A, B and C, which are involved in about 85 percent of all HIV infections around the world. The same prime-boost vaccine combination is being tested in 480 HIV-uninfected subjects through a multinational Phase 2 trial initiated in October 2005. The combination also is being tested in 15 HIV-infected subjects receiving highly active antiretroviral therapy (HAART) through a Phase 1 trial initiated in August 2006.

The fact that the vaccine is also being tested on HIV positive individuals offers hope that a vaccine could provide therapeutic benefit to those already infected with the virus. It remains unclear if such vaccines would allow patients to discontinue medications or would serve to bolster the patient’s immune response in the management of the disease in order to prevent the progression to AIDS.

The news from the conference is some of the first good vaccine news following the results from the largest trial of the ALVAC vaccine. The disappointing ALVAC vaccine results led to the cancellation of a planned large scale trial as well as further doubt that a viable vaccine was feasible. Nonetheless, it appears that some of the new approaches will at least provide needed clues into the mechanisms needed to eventually defeat the virus. Hopefully one of the new candidates will provide the long awaited outcome.

Daniel DiRito | September 1, 2006 | 9:08 AM | link | Comments (0)
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